Dr. Jiri Zavadil has provided bioinformatics analysis support and co-authored the following papers published in high profile biomedical journals.

March 15, 2010

1. Wolf L.V., Yang Y., Wang J., Xie Q., ZAVADIL J., and Cvekl A. Identification of Pax6-dependent Gene Regulatory Networks in the Mouse Lens. PLoS ONE. 2009, Volume 4, Issue 1, e4159.
2. Blum R., Gupta R., Burger P.E., Ontiveros C.S., Salm S.N., Xiong X., Kamb A., Wesche H., Marshall L., Cutler G., ZAVADIL J., Moscatelli D. and Wilson E.L. Molecular Signatures of Prostate Stem Cells Reveal Novel Signaling Pathways and Provide Insights into Prostate Cancer. PLoS ONE. 2009, May 29;4(5):e5722.
3. Buonamici S., Trimarchi T., Ruocco M.G., Reavie L., Cathelin S., Mar B.G., Klinakis A.,  Lukyanov Y., Tseng J.C., Sen F., Gehrie E., Li M., Newcomb E., ZAVADIL J., Meruelo D., Lipp M., Ibrahim S., Efstratiadis A., Zagzag D., Bromberg J.S., Dustin M., and Aifantis I. CCR7 signaling as an essential regulator of CNS infiltration in T cell leukemia. NATURE, 2009, 459:1000-1004.
4. Flaherty M. S., ZAVADIL J., Ekas L. A., Rodrigues, A. B. and Bach, E. A. Genome-wide expression profiling in the Drosophila eye reveals unexpected repression of Notch signaling by the JAK/STAT pathway. DEV DYN, 2009 Sep;238(9):2235-53.
5. Jag U., ZAVADIL J., Stanley F.M. Insulin acts through FOXO3a to activate transcription of PAI-1. MOL ENDOCRINOL. 2009, (10):1587-602.
6. Iglesias-Ussel M.D., ZAVADIL J., Scharff M.D. Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro. J IMMUNOL METHODS. 2009, 31;350(1-2):71-8.
7. Burda P., Curik N., Kokavec J., Basova P., Mikulenkova D., Skoultchi A.I. ZAVADIL J. and Stopka T. PU.1 activation relieves GATA-1-mediated repression on Cebpa and Cbfb during leukemia differentiation. MOL CANCER RES. 2009, (10):1693-703.
8. Bogunovic D., O'Neill D., Belitskaya-Levy I., Vacic V. ,Yu Y.L. Adams S., Darvishian F., Berman R., Shapiro R., Pavlick A., Lonardi S., ZAVADIL J., Osman I., Bhardwaj N. Immune profile and mitotic index of metastatic melanoma lesions enhance clinical staging in predicting patient survival. P NATL ACAD SCI USA. 2009 Dec 1;106(48):20429-34
9. Reavie L., G. Della Gatta, K. Crusio, B. Aranda-Orgilles, S. M. Buckley, B. Thomson, E. Lee, J. Gao, A. L. Bredemeyer, B. A. Helmink, J. ZAVADIL, B. P. Sleckman, T. Palomero, A. Ferrando and I. Aifantis Hematopoietic Stem Cell Differentiation Regulated by a Single Ubiquitin Ligase: Substrate Complex. NAT IMMUNOL.  2010, 11(3):207-15.
10. Maria Sol Flaherty M.S., Salis P., Evans C.J., Ekas L.A., Marouf A., ZAVADIL J., Banerjee U. Bach E.A. chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation and stem cell self-renewal in Drosophila. DEV CELL. 2010, Accepted for publication.