Jinhua Wang, Ph.D.

Assistant Professor, Department of Pediatrics, NYU School of Medicine
Affiliated with NYU Cancer Institute

Dr. Jinhua Wang is an Assistant Research Professor at NYU School of Medicine and a member of the genomics center at the NYU Cancer Institute. Dr. Wang started his graduate PhD training in computational biology and genomics research in the Institute of Biophysics at Chinese Academy of Sciences in 1996. He made significant contribution to several pioneering genome sequencing projects as bioinformatics research manager in Chinese National Human Genome Center during his graduate years.

Dr. Wang joined the computational genomics research group as a post-doctoral research fellow at Cold Spring Harbor Lab in 2001. In CSHL, He focused on developing mathematical and statistical methods to identify functional elements in eukaryotic genomes, especially on sequence elements that regulate gene transcription and pre-mRNA splicing. He successfully developed new algorithms for comparative genomic DNA sequence analysis, alternative splicing transcripts process pipeline, and various programs for data integration in CSHL.
After he finished his post-doctoral training, Dr. Wang moved on to St Jude Children’s Research Hospital and took the bioinformatics research scientist appointment in the SJCRH bioinformatics and biotechnology center in 2004. As the core member in the center, Dr. Wang applied his expertise in computational genomics to a broad range of clinical research projects and provided customized computational analysis for high-throughput genomics projects especially as it relates to high-throughput data mining and modeling, comparative genomics, integrating CNA (copy number abnormality) and gene expression profiling data and novel methods to detect the influence of CNA on splicing and expression of different splicing isoforms.

In the past few years, Dr Wang has been supporting ChIP-on-Chip experiment data analysis for several major projects. He and other CHIBI faculty evaluated and benchmarked all current software tools for ChIP-on-chip data and optimized the peak finding algorithm and developed a specialized data process pipeline. Their work on the analysis of ChIP-on-Chip data, enabled development of new biological hypotheses on gene transcription regulation, transcription factors interaction and function of repetitive human genome sequence elements, which were tested and validated by biologists. These new discoveries were published in several high impact journals including Molecular Cell, PloS ONE, Cell division, and others. Dr Wang’s expertise in sequence motif discovery, peak finding optimization, and global gene regulation study gives a big advantage in the investigation of ChIPseq data and contributes to biological and clinical research at NYU and beyond.

Dr. Wang has published/co-authored 25 peer reviewed journal papers in prestigious and high impact journals such as Science, Molecular Cell, Genome Research, Blood, Human Molecular Genetics and Nucleic Acids Research. Dr. Wang has developed several important genomics informatics databases and widely cited software for genomic sequence motif discovery. Currently, as a leading expert in genome informatics, Dr. Wang is actively involved in next generation sequencing and personalized genome sequencing projects.

Address:
540 First Avenue
Skirball Institute of Biomolecular Medicine, 3rd Fl., Lab. 7
New York University Langone Medical Center
New York, NY 10016, USA
Phone: +1-212-263-6754
Fax: +1-212-263-8951