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Computational Causal Discovery Laboratory
Description:
Extensive research in recent years has shown the critical importance of graph-theoretic, computational causal discovery methods for many fields – and, in particular, with respect to the analyses undertaken within NYU Center for Health Informatics and Bioinformatics on behalf of NYULMC researchers. Several varieties exist with causal Bayesian Networks being a dominant paradigm. For example, causal methods can identify biomarkers that are targets for new drug development or SNPs that likely cause disease; they can indicate membership of genes and proteins in disease-related pathways; and they can lead to more compact and better generalizable molecular signatures compared to the first-generation and less sophisticated differential expression/associative/ad hoc or clustering methods. The purpose of the Computation Causal Discovery laboratory is to develop, test and apply causal methods suitable for clinical, molecular, imaging and multi-modal data of high-dimensionality.
Members:
- Director/Principal Investigator: Alexander Statnikov, Ph.D.
- Senior Advisor: Constantin F. Aliferis, M.D., Ph.D.
- Lead scientific programmer:
Nikita Lytkin, Ph.D. - Scientific programmer (shared with molecular profiles lab): Jizhou Ai, M.S.
- Graduate student: Varun Narendra, M.S.
- Administrative support:
Collaborators outside NYU:
- Laura E. Brown, Ph.D. (Department of Computer Science, Michigan Technological University)
- Gregory Cooper, M.D., Ph.D. (Department of Biomedical Informatics, University of Pittsburgh)
- Isabelle Guyon, Ph.D. (ClopiNet, Berkley, Ca)
- Douglas Hardin, Ph.D. (Department of Mathematics, Vanderbilt University)
- Frank Harrell, Ph.D. (Department of Biostatistics, Vanderbilt University)
- Lewis Frey, Ph.D. (Department of Biomedical Informatics, University of Utah)
- Subramani Mani, Ph.D. (Department of Biomedical Informatics, Vanderbilt University)
- Pierre Massion, M.D. (Department of Medicine, Vanderbilt University)
- Ioannis Tsamardinos, Ph.D. (Department of Computer Science, University of Crete, Greece)
