Genetics-Genomics Informatics
Informatics faculty and staff support in excess of 40 projects/year that utilize a variety of high-dimensional genomic datasets. Most of these projects are published in high-impact journals. The following are examples of complex bioinformatics services/analyses provided by CHIBI experts:
Microarray Informatics
- Experiment design,
- Differential expression,
- Pathway mapping,
- Pathway-specific testing (GSEA/GSA),
- Phylogeny,
- Clustering/visualization,
- Hybrid experimental/observational designs;
- SNP arrays analyses;
- ChIP-on-ChIP analyses,
- aCGH analyses,
- Tiling arrays analyses,
- Exon arrays analyses,
- miRNA arrays analyses,
- Epigenomic arrays analyses
Molecular Signatures & biomarkers for diagnostics, imaging and personalized medicine:
- Development of molecular signatures for diagnosis,
- Development of molecular signatures for outcome prediction (prognostic models), and personalized medicine (predictive models),
- Discovery of diagnostic biomarkers,
- Discovery of imaging biomarkers,
- Discovery of putative drug targets,
- In silico scanning of signatures and putative drug targets,
- Deployment of signatures,
- Automated software,
- New methods for development of signatures and discovery of markers
Causal & Pathway inference
- De novo discovery and refinement of pathways and drug targets,
- Studies/benchmarking of causal validity of bioinformatics discovery methods,
- Automated software,
- Active learning/experiment number minimization
Contacts:
Jiri Zavadil, Yuval Kluger, Jinhua Wang, Constantin Aliferis, Stuart Brown, Alexander Statnikov
